Subject-own-control design in evaluating clinical antidepressant effects
| Autor: | Eberhard H. Uhlenhuth, Stuart Greene, Stanley G. McCracken, Richard M. Glass, William Matuzas |
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| Rok vydání: | 1982 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty Imipramine medicine.drug_class media_common.quotation_subject Crossover Tricyclic antidepressant Double-Blind Method Internal medicine medicine Humans Effects of sleep deprivation on cognitive performance media_common Psychiatric Status Rating Scales Clinical Trials as Topic Depressive Disorder Middle Aged Crossover study Psychiatry and Mental health Clinical Psychology Antianxiety drugs Antidepressant Female Psychology medicine.drug Clinical psychology |
| Zdroj: | Journal of affective disorders. 4(4) |
| ISSN: | 0165-0327 |
| Popis: | This study tested the use of a subject-own-control, multiple crossover design for evaluating the clinical effects of an established tricyclic antidepressant drug, imipramine. Although significant physiological and cognitive performance effects were demonstrated, only one clinical measure, target symptom change rated by the patients, showed a statistically significant drug-placebo difference. This result is in considerable contrast to the sensitivity of similar designs in detecting the clinical effects of antianxiety drugs in studies employing less than 20 patients. Crossover designs appear to be most successful when the treated condition is continuos, rather than episodic, and the treatment effects have a rapid onset and offset. |
| Databáze: | OpenAIRE |
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