COMT and age at onset in mood disorders: a replication and extension study
| Autor: | Massat, I, Kocabas, Na, Crisafulli, Concetta, Chiesa, A, Calati, R, Linotte, S, Kasper, S, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Serretti, A, Mendlewicz, J. |
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| Přispěvatelé: | Massat I., Kocabas N.A., Crisafulli C., Chiesa A., Calati R., Linotte S., Kasper S., Fink M., Antonijevic I., Forray C., Snyder L., Bollen J., Zohar J., De Ronchi D., Souery D., Serretti A., Mendlewicz J., Massat, I, Kocabas, N, Crisafulli, C, Chiesa, A, Calati, R, Linotte, S, Kasper, S, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Serretti, A, Mendlewicz, J |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Genotype early onset Catechol O-Methyltransferase Polymorphism Single Nucleotide Polymorphism (computer science) Internal medicine medicine Humans Genetic Predisposition to Disease Bipolar disorder Allele Age of Onset Psychiatry gene Depression (differential diagnoses) Alleles Early onset Depressive Disorder Major General Neuroscience BIPOLAR DISORDER Middle Aged medicine.disease DEPRESSION COMT Mood disorders Female Psychology rs4680 |
| Popis: | Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG + AG genotypes were more represented in the subgroup of early onset MD patients (p = 0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p = 0.04). Rs4680 genotype was associated with early onset BD as well (p = 0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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