Evaluation of the safety and efficacy of humanized anti-CD19 chimeric antigen receptor T-cell therapy in older patients with relapsed/refractory diffuse large B-cell lymphoma based on the comprehensive geriatric assessment system
| Autor: | Juanxia Meng, Qing Li, Qi Deng, Yanyu Jiang, Cuicui Lyu, Man Liu, Jing-Yi Li, Huan Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Antigens CD19 Cell- and Tissue-Based Therapy Immunotherapy Adoptive Older patients Refractory hemic and lymphatic diseases Internal medicine medicine Humans Adverse effect Geriatric Assessment Aged Receptors Chimeric Antigen business.industry Geriatric assessment Hematology medicine.disease Chimeric antigen receptor Lymphoma Chimeric Antigen Receptor T-Cell Therapy Lymphoma Large B-Cell Diffuse business human activities Diffuse large B-cell lymphoma |
| Zdroj: | Leukemia & Lymphoma. 63:353-361 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has led to unprecedented results to date in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), yet its clinical application in elderly patients with R/R DLBCL remains somewhat limited. In this study, a total of 31 R/R DLBCL patients older than 65 years of age were enrolled and received humanized anti-CD19 CAR T-cell therapy. Patients were stratified into a fit, unfit, or frail group according to the comprehensive geriatric assessment (CGA). The fit group had a higher objective response (OR) rate (ORR) and complete response (CR) rate than that of the unfit/frail group, but there was no difference in the part response (PR) rate between the groups. The unfit/frail group was more likely to experience AEs than the fit group. The peak proportion of anti-CD19 CAR T-cells in the fit group was significantly higher than that of the unfit/frail group. The CGA can be used to effectively predict the treatment response, adverse events, and long-term survival. |
| Databáze: | OpenAIRE |
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