Small molecules aimed at type III secretion systems to inhibit bacterial virulence

Autor:	Lun K. Tsou, Howard C. Hang, Paul D. Dossa
Rok vydání:	2013
Předmět:	Pharmacology Modern medicine medicine.drug_class Effector Organic Chemistry Antibiotics Pharmaceutical Science Virulence Biology Bioinformatics Biochemistry Small molecule Article Microbiology Bacterial virulence Drug Discovery medicine Molecular Medicine Secretion
Zdroj:	MedChemComm. 4(1)
ISSN:	2040-2503
Popis:	The development of new anti-bacterial compounds presents a major challenge to modern medicine as bacterial strains resistant to traditional antibiotics are constantly emerging. Type III secretion systems (T3SSs) are essential for virulence mechanisms of many Gram-negative bacterial pathogens and have therefore emerged as an attractive target for small molecule anti-virulence therapeutics. This has led to several high-throughput screens in search for specific chemicals that inhibit the secretion and translocation of bacterial effector proteins. Several classes of small molecules have now been identified from these screens and this review focuses on their discovery and discusses their potential mechanisms of action and prospects for clinical development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490ed218780785f71eb2d92b0b470bd7 https://pubmed.ncbi.nlm.nih.gov/23930198 Zobrazit plný text záznamu