| Autor: |
Pinckney, Lauren, Collins, Justin, Schammel, Christine, Gevaert, Matt, Schammel, David, W. Edenfield, Jeffrey Elder, Puls, Larry |
| Rok vydání: |
2018 |
| DOI: |
10.6084/m9.figshare.7040858 |
| Popis: |
Figure S2. GPR124, ALK and KMT2D proteins converge on HSP90AA1. An evaluation of the potential role of the gene products from mutated genes in our cohort that are associated with negative outcomes was completed to potentially identify pathways that could be targeted for novel therapy in this young group. StringÂŽ, a protein-protein network modeling website sponsored by the String Consortium and the Swiss Institute of Bioinformatics (SIB) [ http://string-db.org ], was used to postulate how the gene mutations were connected in biochemical pathways that could potentially create the carcinogenic phenotype. Gene mutations in GPR124, ALK and KMT2D (MLL2) were associated with negative outcomes in Sarcome and Neuroendocrine histologies in our cohort and converge on HSP90AA1, a chaperone protein associated with an unfavorable prognosis in both liver and breast cancers. HSP90AA1 is a key regulator in PK1 activity at the G2/M transition of the cell cycle. Inhibition of HSP90AA1 and PK1 halts progression, promoting apoptosis. [ http://string-db.org ]; [ www.genecards.org/cgi-bin/carddisp.pl?gene=HSP90AA1&keywords=HSP90AA1 ]. Both Additional files 4 and 5: Figure S1 and S2 illustrate the complexity of the carcinogenic phenotype and illustrate the variety of pathways available if a single or even multiple pathways are blocked (DOCX 271 kb) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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