The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases

Autor: La Rocca, C, Maranghi, F, Tait, S, Tassinari, R, Baldi, F, Bottaro, G, Buzzigoli, E, Carli, F, Cianfarani, S, Conte, R, Deodati, A, Gastaldelli, A, Pala, Ap, Raffaelli, A, Saponaro, C, Scire, G, Spadoni, Gl, Busani, L, Narciso, L, Baldiniferroli, B, Marini, R, Germani, D, Barsotti, G, Ciociaro, D, Dellalatta, V, Distante, G, Gaggini, M, Landi, P, Di Virgilio, A, Martinelli, A, Valeri, M, Mancini, Fr, Fabbrizi, E, Toffol, G
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Pediatric Obesity
Multivariate analysis
Health
Toxicology and Mutagenesis
Puberty
Precocious
Urine
010501 environmental sciences
Endocrine Disruptors
01 natural sciences
Surveys and Questionnaires
BPA
Children obesity
DEHP
Human biomonitoring
In vivo toxicity
Puberty
Adolescent
Adult
Animals
Benzhydryl Compounds
Child
Child
Preschool
Environmental Exposure
Environmental Monitoring
Environmental Pollutants
Epidemiologic Studies
Female
Humans
Italy
Life Style
Mothers
Phenols
Phthalic Acids
Rats
education.field_of_study
General Medicine
Pollution
Settore MED/38
Risk assessment
endocrine system
Population
03 medical and health sciences
Environmental health
medicine
Environmental Chemistry
Precocious puberty
Endocrine system
Juvenile
education
Preschool
0105 earth and related environmental sciences
business.industry
medicine.disease
Obesity
030104 developmental biology
Precocious
business
Popis: Phthalates and bisphenol A (BPA), plasticizers used in several products of daily life, are considered as endocrine disrupters, therefore children exposure is particularly relevant. The LIFE PERSUADED project aims to define the following: (a) the evaluation of internal levels of DEHP's metabolites and BPA in Italian children and their mothers, (b) the association of the exposure with puberty development and obesity diseases, and (c) the effects of exposure in juvenile in vivo model. The cross-sectional study has involved 2160 mother-child pairs, including males and females, children and adolescents, from urban and rural areas of North, Center, and South Italy. A structured questionnaire and a food diary are designed to evaluate the association between lifestyle variables potentially related to DEHP/BPA exposure and internal levels, through univariate and multivariate analyses. Two pilot case-control studies are carried out on idiopathic premature thelarche and precocious puberty (30 girls each group, aged 2-7 years) and idiopathic obesity (30 boys and 30 girls, aged 6-10 years), matched to healthy controls. BPA and DEHP's metabolites are analyzed in urine samples from all recruited subjects. Clinical and toxicological biomarkers are evaluated in serum of case-control subjects. Moreover, the toxicity study is carried out in a juvenile rodent model exposed to mixtures of BPA and DEHP at dose levels recorded in children population. The scientific results of LIFE PERSUADED will contribute to risk assessment of BPA and DEHP.
Databáze: OpenAIRE
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