Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children
| Autor: | Zeynep Şıklar, Bayram Özhan, Seda Topçu, Tufan Aç, Şatıroğlu Tufan Nl, Merih Berberoğlu, Mesut Akyol, Şimşek Orhon F, Afra Alkan, Betül Ulukol, Sevgi Başkan |
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| Rok vydání: | 2017 |
| Předmět: |
Male
obesity puberty Pediatric Obesity Turkey Endocrinology Diabetes and Metabolism Ideal Body Weight Endokrinoloji ve Metabolizma Pediatri Growth Overweight preschool child Body Mass Index 0302 clinical medicine Endocrinology newborn blood analysis Natriuretic peptide Medicine Child 2. Zero hunger amino-terminal pro-C-type natriuretic peptide human adult Adolescent Biomarkers/*blood Child Preschool Female Humans Ideal Body Weight/*physiology Infant Infant Newborn Natriuretic Peptide C-Type/*blood Pediatric Obesity/*blood/epidemiology Turkey/epidemiology biological marker Turkish citizen 3. Good health female natriuretic peptide type C biomarker body height Biomarker (medicine) Original Article growth rate medicine.symptom childhood obesity Turkish population medicine.medical_specialty medicine.drug_class growth 030209 endocrinology & metabolism Article Childhood obesity 03 medical and health sciences blood Internal medicine overweight Obesity human amino-terminal propeptide of C-type natriuretic peptide plasma business.industry Natriuretic Peptide C-Type Biomarker Amino-terminal propeptide of C-type natriuretic peptide Anthropometry school child medicine.disease major clinical study body mass enzyme linked immunosorbent assay physiology Pediatrics Perinatology and Child Health amino terminal sequence business Body mass index C-type natriuretic peptide Biomarkers 030217 neurology & neurosurgery anthropometric parameters |
| Zdroj: | Europe PubMed Central Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5727 |
| DOI: | 10.4274/jcrpe.4543 |
| Popis: | Objective: In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children, CNP has been implicated as an emerging new growth marker during childhood. It has been reported that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population. Methods: Consent was taken from 317 children [ages 0-18 (158 girls, 159 boys)] and their parents. All subjects were physically examined; anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken. Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay. Results: Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the age-dependent plasma NT-proCNP concentration until puberty. Conclusion: Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential biomarker in childhood obesity. Further studies are necessary to address this question. © 2017 by Turkish Pediatric Endocrinology and Diabetes Society. |
| Databáze: | OpenAIRE |
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