Effect of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid oxidation in rat skeletal muscle
| Autor: | Ching K. Chow, Gilbert A. Boissonneault, Wendy K. M. Chan, Eric A. Decker |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Antioxidant Clinical chemistry Thiobarbituric acid medicine.medical_treatment Anserine Carnosine Biochemistry Thiobarbituric Acid Reactive Substances Antioxidants chemistry.chemical_compound Lipid oxidation Internal medicine TBARS medicine Animals Vitamin E heterocyclic compounds Histidine Muscle Skeletal Myocardium Organic Chemistry food and beverages Skeletal muscle Cell Biology Diet Rats medicine.anatomical_structure Endocrinology chemistry Liver lipids (amino acids peptides and proteins) |
| Zdroj: | Lipids. 29(7) |
| ISSN: | 0024-4201 |
| Popis: | The effect of dietary carnosine supplementation on plasma and tissue carnosine and alpha-tocopherol concentrations and on the formation of thiobarbituric acid reactive substances (TBARS) in rat skeletal muscle homogenates was evaluated. Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm). Dietary carnosine supplementation did not increase carnosine concentrations in heart, liver and skeletal muscle. Dietary supplementation with both carnosine and alpha-tocopherol increased carnosine concentrations in liver 1.56, 1.51- and 1.51-fold as compared with diets lacking carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol, respectively. Dietary supplementation with both carnosine and alpha-tocopherol also increased alpha-tocopherol concentrations in heart and liver 1-38-fold and 1.68-fold, respectively, as compared to supplementation with alpha-tocopherol alone. Dietary supplementation with carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol was effective in decreasing the formation of TBARS in rat skeletal muscle homogenate, with dietary alpha-tocopherol and alpha-tocopherol plus carnosine being more effective than dietary carnosine alone. The data suggest that dietary supplementation with carnosine and alpha-tocopherol modulates some tissue carnosine and alpha-tocopherol concentrations and the formation of TBARS in rat skeletal muscle homogenates. |
| Databáze: | OpenAIRE |
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