MKK7 and ARF
| Autor: | Paul A. Townsend, Daniel Schramek, Josef M. Penninger, Athanassios Kotsinas, Jiri Bartek, Panagiota Papanagnou, Vassilis G. Gorgoulis, Panagiotis Galanos |
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| Rok vydání: | 2014 |
| Předmět: |
Reading Frames
DNA Repair DNA repair DNA damage p38 mitogen-activated protein kinases MAP Kinase Kinase 7 Ataxia Telangiectasia Mutated Proteins Biology p38 Mitogen-Activated Protein Kinases MAP2K7 03 medical and health sciences 0302 clinical medicine Animals Humans Phosphorylation Protein kinase A Molecular Biology 030304 developmental biology Extra Views 0303 health sciences Effector Oncogenes Cell Biology Cell biology body regions 030220 oncology & carcinogenesis Tumor Suppressor Protein p53 Signal transduction DNA Damage Signal Transduction Developmental Biology |
| Zdroj: | Cell Cycle. 13:1227-1236 |
| ISSN: | 1551-4005 1538-4101 |
| Popis: | Sensing, integrating, and processing of stressogenic signals must be followed by accurate differential response(s) for a cell to survive and avoid malignant transformation. The DNA damage response (DDR) pathway is vital in this process, as it deals with genotoxic/oncogenic insults, having p53 as a nodal effector that performs most of the above tasks. Accumulating data reveal that other pathways are also involved in the same or similar processes, conveying also to p53. Emerging questions are if, how, and when these additional pathways communicate with the DDR axis. Two such stress response pathways, involving the MKK7 stress-activated protein kinase (SAPK) and ARF, have been shown to be interlocked with the ATM/ATR-regulated DDR axis in a highly ordered manner. This creates a new landscape in the DDR orchestrated response to genotoxic/oncogenic insults that is currently discussed. |
| Databáze: | OpenAIRE |
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