Cytotoxicity and Sensitization of Povidone-lodine and Other Frequently Used Anti-Infective Agents
Autor: | R. Niedner |
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Rok vydání: | 1997 |
Předmět: |
medicine.drug_class
Detergents Antibiotics Dermatology Drug Hypersensitivity Iodophors Antiseptic In vivo medicine Animals Humans Cytotoxicity Povidone-Iodine Sensitization Skin Wound Healing business.industry Neomycin In vitro Anti-Bacterial Agents medicine.anatomical_structure Immunology Anti-Infective Agents Local business Wound healing medicine.drug |
Zdroj: | Dermatology. 195:89-92 |
ISSN: | 1421-9832 1018-8665 |
DOI: | 10.1159/000246038 |
Popis: | Povidone-iodine is an antiseptic widely used in dermatology. In vitro experiments showed a certain cytotoxicity, yet it is not easy to transfer these toxicological data to in vivo circumstances. In vivo investigations in animals and in humans could exclude cytotoxic effects of povidone-iodine, measured by the wound healing process. Only when administered in combination with detergents was an obvious cytotoxicity seen in wounds but not on the intact skin. In comparison to the frequently used antibiotic neomycin, the sensitization rate of povidone-iodine is very low. |
Databáze: | OpenAIRE |
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