Insulin resistance in HIV protease inhibitor-associated diabetes
| Autor: | Samuel Dagogo-Jack, Philippe A. Halban, Alan Bohrer, John Turk, Catherine Sigmund, Kevin E. Yarasheski, Pablo Tebas, Philip E. Cryer, William G. Powderly |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_treatment HIV Infections Indinavir HIV Protease Inhibitors/ adverse effects/therapeutic use Phospholipases A/metabolism Rats Sprague-Dawley chemistry.chemical_compound C-Peptide/metabolism Insulin Pharmacology (medical) ddc:576.5 Indinavir/ adverse effects/therapeutic use Cells Cultured Proinsulin C-Peptide C-peptide virus diseases HIV Infections/ complications/drug therapy Infectious Diseases Anti-HIV Agents/ adverse effects/therapeutic use Islets of Langerhans/metabolism medicine.drug Adult medicine.medical_specialty Insulin/metabolism Anti-HIV Agents Glucagon Article Phospholipases A Islets of Langerhans Insulin resistance Internal medicine Diabetes mellitus medicine Animals Humans Glucagon/metabolism business.industry HIV Protease Inhibitors Proinsulin/metabolism medicine.disease Rats Diabetes Mellitus Type 1 Endocrinology Cross-Sectional Studies chemistry Diabetes Mellitus Type 1/ complications Insulin Resistance business Hormone |
| Zdroj: | Journal of Acquired Immune Deficiency Syndromes, Vol. 21, No 3 (1999) pp. 209-216 |
| ISSN: | 1525-4135 |
| Popis: | BACKGROUND: Fasting hyperglycemia has been associated with HIV protease inhibitor (PI) therapy. OBJECTIVE: To determine whether absolute insulin deficiency or insulin resistance with relative insulin deficiency and an elevated body mass index (BMI) contribute to HIV PI-associated diabetes. DESIGN: Cross-sectional evaluation. PATIENTS: 8 healthy seronegative men, 10 nondiabetic HIV-positive patients naive to PI, 15 nondiabetic HIV-positive patients receiving PI (BMI = 26 kg/m2), 6 nondiabetic HIV-positive patients receiving PI (BMI = 31 kg/m2), and 8 HIV-positive patients with diabetes receiving PI (BMI = 34 kg/m2). All patients on PI received indinavir. MEASUREMENTS: Fasting concentrations of glucoregulatory hormones. Direct effects of indinavir (20 microM) on rat pancreatic beta-cell function in vitro. RESULTS: In hyperglycemic HIV-positive subjects, circulating concentrations of insulin, C-peptide, proinsulin, glucagon, and the proinsulin/insulin ratio were increased when compared with those of the other 4 groups (p |
| Databáze: | OpenAIRE |
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