Remifentanil protects uterus against ischemia-reperfusion injury in rats
| Autor: | Sadik Sahin, Ozlem Bingol Ozakpinar, Serap Aktas, Yunus Oktay Atalay, Zafer Kucukodaci |
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| Přispěvatelé: | OMÜ |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Time Factors RD1-811 Uterus Ischemia Remifentanil Antioxidants Random Allocation chemistry.chemical_compound Piperidines Malondialdehyde Internal medicine medicine Animals Leukocytosis Rats Wistar Transplantation Superoxide Dismutase business.industry Reproducibility of Results Uterine horns Catalase medicine.disease Rats Analgesics Opioid Endocrinology medicine.anatomical_structure chemistry Reperfusion Injury Anesthesia Female Surgery medicine.symptom business Reperfusion injury medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 30, Issue: 11, Pages: 756-761, Published: NOV 2015 Acta Cirúrgica Brasileira v.30 n.11 2015 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 30, Iss 11, Pp 756-761 (2015) |
| ISSN: | 0102-8650 |
| DOI: | 10.1590/s0102-865020150110000006 |
| Popis: | Sahin, Sadik/0000-0002-7107-9719 WOS: 000367014300006 PubMed: 26647795 PURPOSE: To investigate the effects of remifentanil as an antioxidant and analyze the histopathologic, biochemical changes in experimental ischemia-reperfusion (I/R) exposed rat uteri. METHODS: Wistar albino rats were assigned to three groups (n = 7). 2h period of ischemia was followed by 1h of reperfusion in the I/R and the I/R-remifentanil groups. After ischemia, no drug was administered in the sham and I/R groups. In the I/R-remifentanil group, remifentanil infusion (2 mu g/kg/min) was started in the ischemia period, and continued until the end of reperfusion. After the ischemic and reperfusion period, the ischemic uterine horns were removed surgically for biochemical and histopathologic examination. Tissue damage scores (endometrial epithelial glandular leukocytosis, degeneration, and endometrial stromal changes) were examined. Malondialdehyde levels and catalase, superoxide dismutase enzyme activities in tissue were measured. RESULTS: We found significantly lower epithelial leukocytosis and cell degeneration in the I/R-remifentanil group (p |
| Databáze: | OpenAIRE |
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