Detection of Genetic Variants of Haemophilia B with an Immunosorbent Technique
| Autor: | D. T. Tayloe, Harold R. Roberts, W. R. Neal, Arthur I. Cederbaum |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Immunosorbent technique
Genetic variants Genetic Variation Hematology Cross Reactions Biology medicine.disease Haemophilia Hemophilia B Virology Diagnosis Differential Factor IX Specific antibody Neutralization Tests medicine biology.protein Humans Haemophilia B Adsorption Barium Sulfate Antibody Cellulose Autoantibodies |
| Zdroj: | British Journal of Haematology. 25:63-68 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1973.tb01716.x |
| Popis: | Summary. With an immunosorbent technique, we have found multiple genetic variants of haemophilia B. In one variant there is no detectable material that cross-reacts with a human anti-factor-IX antibody. This variant is defined as negative for cross-reacting material (CRM−). There is also a CRM+ variant in which the factor-IX deficient plasma has the capacity to neutralize as much antibody as does normal plasma. There is an intermediate variety that neutralizes the specific antibody to a degree which is proportional to the factor-IX clotting activity. This last group has been designated as having reduced cross-reacting material (CRMR). The CRMR group is probably heterogeneous, and it is likely that many genetic variants of haemophilia B exist. |
| Databáze: | OpenAIRE |
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