Apolipoprotein E genotype in senile dementia and Down's syndrome

Autor:	Mariagrazia Cova, Anthony Ryan, Margherita Casartelli, Ludovica Caputo, Giorgio Annoni, Carlo Vergani
Rok vydání:	1997
Předmět:	Apolipoprotein E Aging medicine.medical_specialty Pathology Health (social science) S syndrome business.industry Healthy elderly Disease Senile dementia medicine.disease Gastroenterology Internal medicine Genotype medicine Geriatrics and Gerontology Allele business Vascular dementia Gerontology
Zdroj:	Archives of Gerontology and Geriatrics. 26:15-21
ISSN:	0167-4943
DOI:	10.1016/s0167-4943(97)00025-3
Popis:	Apolipoprotein E genotypes were determined in 30 healthy elderly controls, 42 patients with Alzheimer's disease, 13 subjects with vascular dementia and 31 individuals with Down's syndrome. The frequency of epsilon4 allele carriers was significantly increased in the Alzheimer's disease group (chi(2)=4.918, P0.05) but also in the vascular dementia subjects (P0.01, Fisher's exact test). The established relationship between genotype and age at onset of Alzheimer's disease was not statistically significant in these data. Frequencies of the genotypes in the Down's syndrome group did not differ from those of controls. The results obtained in this sample of the Italian population suggest that the apolipoprotein E genotype may be of limited use in the differential diagnosis of dementia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49044c9d3f1993fd3075ea894ac5535d https://doi.org/10.1016/s0167-4943(97)00025-3 Zobrazit plný text záznamu Full Text from ScienceDirect