New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation

Autor: Edward J. Vigmond, Thomas Desplantez, Natalia A. Trayanova, William H. Franceschi, Claudia Hawks, Marion Constantin, Patrick M. Boyle
Přispěvatelé: Johns Hopkins University (JHU), Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad de Navarra [Pamplona] (UNAV), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Modélisation et calculs pour l'électrophysiologie cardiaque (CARMEN), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Vigmond, Edward, Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux]
Rok vydání: 2018
Předmět:
0301 basic medicine
Source-sink mismatch
Conduction velocity
[SDV]Life Sciences [q-bio]
Cardiac electrophysiology
Action Potentials
030204 cardiovascular system & hematology
Cardiac excitability
Synthetic data
Nerve conduction velocity
Article
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Robustness (computer science)
Heart Rate
Range (statistics)
Animals
Humans
Myocytes
Cardiac
Molecular Biology
Cardiac safety factor
Physics
[SDV.IB] Life Sciences [q-bio]/Bioengineering
Computational model
Sodium channel
Myocardium
Models
Cardiovascular
Cardiac arrhythmia
Arrhythmias
Cardiac
Thermal Conductivity
Thermal conduction
Fibrosis
Myocardial Contraction
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Electrophysiological Phenomena
[SDV] Life Sciences [q-bio]
030104 developmental biology
Heart Block
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Cardiology and Cardiovascular Medicine
Biological system
Zdroj: Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2019, 128, pp.117-128. ⟨10.1016/j.yjmcc.2019.01.010⟩
Journal of Molecular and Cellular Cardiology, 2019, 128, pp.117-128. ⟨10.1016/j.yjmcc.2019.01.010⟩
ISSN: 1095-8584
0022-2828
DOI: 10.1016/j.yjmcc.2019.01.010⟩
Popis: International audience; Cardiac conduction disturbances are linked with arrhythmia development. The concept of safety factor (SF) has been derived to describe the robustness of conduction, but the usefulness of this metric has been constrained by several limitations. For example, due to the difficulty of measuring the necessary input variables, SF calculations have only been applied to synthetic data. Moreover, quantitative validation of SF is lacking; specifically, the practical meaning of particular SF values is unclear, aside from the fact that propagation failure (i.e., conduction block) is characterized by SF
Databáze: OpenAIRE
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