Evaluation of different concentrations of hydrogen peroxide solution (3% and 6%) as a potential new therapeutic option of nongenital warts: A randomized controlled triple-blinded clinical trial
| Autor: | Shimaa A. Elghazally, Aya Y. Badran, Ayman M. Mahran, Howida Twisy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Administration Topical Urology Dermatology Occlusive Dressings Skin infection Placebo law.invention 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Randomized controlled trial law Occlusion medicine Humans Prospective Studies Hydrogen peroxide Child Saline Hypopigmentation Dose-Response Relationship Drug business.industry Hydrogen Peroxide Middle Aged medicine.disease Oxidants Clinical trial Treatment Outcome chemistry 030220 oncology & carcinogenesis Child Preschool Female medicine.symptom Warts business |
| Zdroj: | Journal of cosmetic dermatologyREFERENCES. 19(2) |
| ISSN: | 1473-2165 |
| Popis: | Background Warts are common viral skin infections caused by human papillomavirus. None of the available treatment modalities fulfills the criteria of an ideal treatment option. Objectives To evaluate the efficacy and safety of hydrogen peroxide (HP) 3% and 6% solution as a topical treatment of nongenital warts. Methods This prospective randomized controlled study included 145 patients with nongenital warts. They were divided into three groups. Group 1 used topical hydrogen peroxide 6% solution under occlusion with a plastic tape for one hour daily for 6 weeks, group 2 used hydrogen peroxide 3% solution, and group 3 used normal saline 0.9% as a placebo. Patients were evaluated at the third and sixth weeks of treatment and 12 weeks after treatment completion. Results Treatment responses were significantly better in groups 1 and 2 than in group 3 with a better overall responses in group 1 than in group 2 (P = 0.0001*). Apart from mild hypopigmentation which was detected in only two patients in groups 1 and 2, no other side effects could be detected. Three months after treatment completion, no recurrence was observed. Conclusion Hydrogen peroxide solution (3% and 6%) is an effective, safe, and cheap treatment modality for nongenital warts which can be used simply at home. Since the overall response was better with the 6% concentration, it should be the better therapeutic option. |
| Databáze: | OpenAIRE |
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