Autor: |
Bin‐Tong Xia, Yan He, Yang Guo, Jiao‐Long Huang, Xiao‐Juan Tang, Jian‐Ru Wang, Yan Tan, Peng Duan |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Environmental toxicologyREFERENCES. 37(5) |
ISSN: |
1522-7278 |
Popis: |
Bisphenol A (BPA) and 4-nonylphenol (NP) are well-known endocrine-disrupting chemicals (EDCs) that have been proven to affect Leydig cell (LC) functions and testosterone production, but whether BPA and NP have multi- and transgenerational biochemical effects on Leydig cells (LCs) is unknown. Fourier transform infrared (FTIR) spectroscopy is a powerful analytical technique that enables label-free and non-destructive analysis of the tissue specimen. Herein we employed FTIR coupled with chemometrics analysis to identify biomolecular changes in testicular interstitial (Leydig) cells of rats after chronic exposure to low doses of BPA and NP. Cluster segregations between exposed and control groups were observed based on the fingerprint region of 1800-900 cm |
Databáze: |
OpenAIRE |
Externí odkaz: |
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