Multi- and transgenerational biochemical effects of low-dose exposure to bisphenol A and 4-nonylphenol on testicular interstitial (Leydig) cells

Autor:	Bin‐Tong Xia, Yan He, Yang Guo, Jiao‐Long Huang, Xiao‐Juan Tang, Jian‐Ru Wang, Yan Tan, Peng Duan
Rok vydání:	2021
Předmět:	Male Phenols Health Toxicology and Mutagenesis Animals Leydig Cells General Medicine Management Monitoring Policy and Law Benzhydryl Compounds Endocrine Disruptors Toxicology Rats
Zdroj:	Environmental toxicologyREFERENCES. 37(5)
ISSN:	1522-7278
Popis:	Bisphenol A (BPA) and 4-nonylphenol (NP) are well-known endocrine-disrupting chemicals (EDCs) that have been proven to affect Leydig cell (LC) functions and testosterone production, but whether BPA and NP have multi- and transgenerational biochemical effects on Leydig cells (LCs) is unknown. Fourier transform infrared (FTIR) spectroscopy is a powerful analytical technique that enables label-free and non-destructive analysis of the tissue specimen. Herein we employed FTIR coupled with chemometrics analysis to identify biomolecular changes in testicular interstitial (Leydig) cells of rats after chronic exposure to low doses of BPA and NP. Cluster segregations between exposed and control groups were observed based on the fingerprint region of 1800-900 cm
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490165857c44a9f30e9f1fdcede7f326 https://pubmed.ncbi.nlm.nih.gov/35005817 Zobrazit plný text záznamu Plný text