Vascular endothelial cells: Targets for studying the activity of hair follicle cell-produced VEGF
| Autor: | Y. Gall, M. Charveron, J L Bonafé, Jean Plouët, S. Lachgar |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Health Toxicology and Mutagenesis Cell Stimulation Endothelial Growth Factors Biology Toxicology law.invention chemistry.chemical_compound Fetus law Internal medicine medicine Animals Secretion Rats Wistar Aorta Cells Cultured Lymphokines Vascular Endothelial Growth Factors Cell Biology Hair follicle Molecular biology Rats Vascular endothelial growth factor Vascular endothelial growth factor A medicine.anatomical_structure Endocrinology chemistry Vascular endothelial growth factor C embryonic structures Recombinant DNA Cattle Endothelium Vascular Hair Follicle |
| Zdroj: | Cell Biology and Toxicology. 12:331-334 |
| ISSN: | 1573-6822 0742-2091 |
| DOI: | 10.1007/bf00438166 |
| Popis: | Fetal bovine aortic endothelial cells (FBAEC) were exposed to purified fractions of conditioned medium from cultures of hair dermal papilla cells (DPC) to determine the existence of any vascular endothelial growth factor (VEGF)-like paracrine activity of the latter. Such fractions were tested for stimulation of growth and migration of cultured FBAEC. In addition, VEGF secretion by DPC was measured by radioassay of VEGF receptors using FBAEC as target cells. The results showed that stimulation of FBAEC proliferation and migration following exposure to purified conditioned medium was dose-dependent. Radioreceptor assays of recombinant VEGF and purified DPC-conditioned medium showed competitive VEGF binding in FBAEC. |
| Databáze: | OpenAIRE |
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