The Effect of Calcium Carbonate and Cholecalciferol on Pharmacokinetic Interaction of 99mTc-CTMP Radiopharmaceuticals for Bone Scanning in Rats (Rattus norvegicus)
| Autor: | Isti Daruwati, Isa Mahendra, T. H. Ambarwibawa, W. Nuraeni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
cholecalciferol
Nuclear and High Energy Physics medicine.medical_specialty Radiation pharmacokinetics interaction Tail vein lcsh:TK9001-9401 Excretion 99mtc-ctmp chemistry.chemical_compound Bone scanning Calcium carbonate Endocrinology Nuclear Energy and Engineering chemistry Pharmacokinetics Internal medicine medicine Distribution (pharmacology) lcsh:Nuclear engineering. Atomic power Radiology Nuclear Medicine and imaging calcium carbonate Cholecalciferol Waste Management and Disposal Pharmacokinetic interaction |
| Zdroj: | Atom Indonesia, Vol 44, Iss 2, Pp 69-73 (2018) |
| ISSN: | 0126-1568 |
| Popis: | Hypocalcemia is one of manifestation of bone metastases which could be treated using calcium carbonate and chole calciferol. Tc-99 m radiolabeled 1,4,8,11-tetraazacyclo tetradecyl-1,4,8,11-tetramethylene phosponic acid ( against 99m Tc-CTMP ) on the other hand is a radioactive complex compound which has an affinity toward bone. Therefore, it could be used as bone tracer (radiopharmaceutical) in bone imaging. However, there has been a concern regarding the use 99m Tc- CTMP on patients who have been treated with calcium carbonate and chole calciferol . In this circumstance 99m Tc- CTMP could interact with calcium carbonate and chole calciferol and it might then interefere with the imaging results. Therefore, th e aim of this study was to determine the pharmacokinetic behavior of 99m Tc-CTMP in rats ( Rattus norvegicus ) that had been previously treated with calcium carbonate and cholecalciferol. The pharmacokinetic studies were performed using four groups of animal model and each groups consists of three rats. The groups were classified as control (I) , rats treated with calcium carbonate (II) , rats treated with chole calciferol (III) , and rats treated with both calcium carbonate and cholecalciferol (IV) . After the rats were treated for 3 days , 99m Tc-CTMP radiopharmaceutical was injected through a tail vein of each rat. At specific time intervals after 99m Tc-CTMP administration , blood was then extracted from the tail , weigh ed and counted using a single channel analyzer. The percentage of r adioactivity in blood at a certain interval was then calculated to determine the distribution half-time and the elimination half-time. The distribution half-time of group I, II, II, and IV were 0.43 + 0.1 3 , 0.2 5 + 0.1 8 , 0.32 + 0.10, and 0.47 + 0.07 hours, respectively, while the elimination half-time were 2.56 + 0.1 8 , 4.48 + 0.5 6 , 4.47 + 1.13, 6.19 + 1.9 7 respectively. The results of T-test showed that there was no significant difference of distribution half-time between the three treated groups and the control group. However, there was significant difference of elimination half-time between the three treatment groups and control. This research showed that giving calcium carbonate or, chole calciferol, and both for 3 days prior administration of 99m Tc-CTMP would mantain elimination half-time which resulted in longer excretion / elimination time. |
| Databáze: | OpenAIRE |
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