Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa
| Autor: | M.J. Neal, C. Jomary, S.E. Jones |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male DNA Complementary genetic structures Chromosomes Human Pair 22 Molecular Sequence Data Biophysics Clone (cell biology) Apoptosis Tissue inhibitor of metalloproteinase Biology Biochemistry Retina Extracellular matrix Structural Biology Sequence Homology Nucleic Acid Complementary DNA Retinitis pigmentosa Gene expression Genetics medicine Humans RNA Messenger Molecular Biology Gene Aged Aged 80 and over Tissue Inhibitor of Metalloproteinase-3 Messenger RNA Base Sequence Chromosome Mapping Metalloendopeptidases Sequence Analysis DNA Cell Biology Middle Aged medicine.disease Molecular biology eye diseases Extracellular Matrix Neoplasm Proteins Gene Expression Regulation Female sense organs Retinitis Pigmentosa |
| Zdroj: | FEBS Letters. 352:171-174 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(94)00951-1 |
| Popis: | To explore the molecular and cellular mechanisms associated with photoreceptor death in retinitis pigmentosa (RP), we have investigated altered transcriptional activity in RP retinas by a differential cDNA screening approach. We identified a clone (K222) showing over-expression in simplex RP retinas compared with controls. K222 encodes a partial cDNA of the human tissue inhibitor of metalloproteinases-3 (TIMP3) gene, a member of a family of genes implicated in extracellular matrix (ECM) remodelling. Increased expression of TIMP3 in degenerating RP retinas may reflect restructuring of the ECM architecture, and disruption of photoreceptor—matrix interactions could contribute to activation of apoptotic cell death processes. |
| Databáze: | OpenAIRE |
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