Neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) in treatment resistant depression

Autor: George Foussias, Nigel C. Rogasch, Daniel M. Blumberger, Faranak Farzan, Reza Zomorrodi, Daphne Voineskos, Zafiris J. Daskalakis, Tarek K. Rajji
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_treatment
Prefrontal Cortex
Electroencephalography
behavioral disciplines and activities
050105 experimental psychology
Double blind
03 medical and health sciences
0302 clinical medicine
GABA receptor
Physiology (medical)
mental disorders
Humans
Medicine
0501 psychology and cognitive sciences
Mean field analysis
Evoked Potentials
N100
medicine.diagnostic_test
Depression
business.industry
musculoskeletal
neural
and ocular physiology
05 social sciences
Neural Inhibition
Middle Aged
Neurophysiology
medicine.disease
Transcranial Magnetic Stimulation
Sensory Systems
Transcranial magnetic stimulation
nervous system
Neurology
Female
Neurology (clinical)
business
Treatment-resistant depression
Neuroscience
psychological phenomena and processes
030217 neurology & neurosurgery
Zdroj: Clinical Neurophysiology. 132:2306-2316
ISSN: 1388-2457
Popis: Repetitive transcranial magnetic stimulation (rTMS) is effective for treatment resistant depression (TRD), but little is known about rTMS' effects on neurophysiological markers. We previously identified neurophysiological markers in depression (N45 and N100) of GABA receptor mediated inhibition. Here, we indexed TMS-electroencephalographic (TMS-EEG) effects of rTMS.TMS-EEG data was analyzed from a double blind 2:1 randomized active (10 Hz left/bilateral):sham rTMS TRD trial. Participants underwent TMS-EEG over left dorsolateral prefrontal cortex (DLPFC) before and after 6 weeks of rTMS. 30 had useable datasets. TMS-evoked potentials (TEP) and components (N45, N100, P60) were examined with global mean field analysis (GMFA) and locally in DLPFC regions of interest.The N45 amplitude differed between active and sham groups over time, N100 amplitude did not. N45 (t = 2.975, p = 0.007) and N100 amplitudes (t = 2.177, p = 0.042) decreased after active rTMS, demonstrating alterations in cortical inhibition. TEP amplitudes decreased after active rTMS in left (t = 4.887, p 0.001) and right DLPFC (t = 4.403, p 0.001) not sham rTMS, demonstrating alterations in cortical excitability.Our results provide important new knowledge regarding rTMS effects on TMS-EEG measures in TRD, suggesting rTMS reduces neurophysiological markers of inhibition and excitability.These findings uncover potentially important neurophysiological mechanisms of rTMS action.
Databáze: OpenAIRE
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