Induction of dendritic cell maturation by IL-18
| Autor: | David Peritt, Jackson Wan, Li Li, Li Sun, Jian Li, Theresa J Goletz, Don E. Griswold, M. Lamine Mbow, Gaoyun Yang, David Shealy, Allen Schantz |
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| Rok vydání: | 2004 |
| Předmět: |
Receptors
Interleukin-18 CD40 biology Follicular dendritic cells Immunology Antigen presentation Interleukin-18 Dendritic Cells Receptors Interleukin Dendritic cell Endocytosis Cell Line Up-Regulation Cell biology B-1 cell Gene Expression Regulation Interleukin 15 Interleukin 12 biology.protein Humans Lymphocyte Culture Test Mixed Antigen-presenting cell Interleukin-18 Receptor alpha Subunit |
| Zdroj: | Cellular Immunology. 227:103-108 |
| ISSN: | 0008-8749 |
| Popis: | IL-18 is a pluripotent proinflammatory cytokine produced primarily by antigen presenting cells involved in numerous aspects of immune regulation most notably on lymphoid cells. The effect of IL-18 stimulation on cells in the myeloid compartment, however, has been poorly studied. Human monocytes did not respond to IL-18. However, the human myelomonocytic cell line KG-1 and monocyte-derived dendritic cells (generated by GM-CSF+IL-4) showed a marked increase in CD83, HLA-DR, and several costimulatory molecules upon stimulation with IL-18. Furthermore, IL-18 decreased pinocytosis of these cells and increased their ability to stimulate alloreactive T cell proliferation, all characteristics of mature dendritic cells. These results suggest that IL-18 is involved in the maturation of myeloid DCs, but not differentiation of monocytes into DCs. The finding that IL-18 is involved in the maturation of dendritic cells is both novel and unexpected and indicates another important role for IL-18 as a key regulator of immune responses. |
| Databáze: | OpenAIRE |
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