Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development
| Autor: | André Tadeu Gotardo, Vânius Vinicius Dipe, Silvana Lima Górniak, Mitsue Haraguchi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Combination therapy
Cyclophosphamide lcsh:Biotechnology Pharmacology Leucaena leucocephala Anticancer activity chemistry.chemical_compound lcsh:TP248.13-248.65 Ascites medicine Effective treatment Mimosine Tumor growth Multidisciplinary biology Chemistry Ehrlich tumor biology.organism_classification Toxicity Immunology medicine.symptom TUMOR DE EHRLICH ANIMAL medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Brazilian Archives of Biology and Technology, Vol 55, Iss 6, Pp 871-876 (2012) Brazilian Archives of Biology and Technology, Volume: 55, Issue: 6, Pages: 871-876, Published: DEC 2012 Brazilian Archives of Biology and Technology v.55 n.6 2012 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
| Popis: | The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide (CY) on tumor growth were also assessed. Mice were divided into groups that received the following treatments over the course of 20 days: phosphate buffer solution (CO), MI, Ehrlich cells (E), E plus CY (EC), E plus MI (EM) and E plus MI and CY (EMC). No signs of toxicity were detected in the mice from the MI group. The mice from the EMC group showed reductions in body weights when compared with those from the E group. The animals from the EC, EM and EMC groups showed reductions in ascitic volume compared with those from the E group. The mice from the EMC group showed reductions in total cell numbers of ascitic fluid compared with those from the E, EC and EM groups. The combination of MI and CY was the most effective treatment for Ehrlich tumor ascites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|