Impact and effectiveness of pentavalent rotavirus vaccine in children5 years of age in Burkina Faso
| Autor: | Madibèlè Kam, Lassana Sangaré, Negar Aliabadi, Jacqueline E. Tate, Rasmata Ouédraogo-Traoré, Moumouni Nikiema, Diarra Yé, Ma Ouattara, Jason M. Mwenda, Umesh D. Parashar, Joseph Nsiari-Muzeyi Biey, Ludovic Kam, Eyal Leshem, Boureima Ouedraogo, Désiré Nezien, Isaïe Medah, Isidore Juste O. Bonkoungou, Maxime Drabo, Souleymane Konaté |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Rotavirus Pediatrics medicine.medical_specialty Genotype 030106 microbiology Rotavirus gastroenteritis Logistic regression medicine.disease_cause Vaccines Attenuated Rotavirus Infections Article 03 medical and health sciences Feces 0302 clinical medicine Burkina Faso Medicine Humans 030212 general & internal medicine General Veterinary General Immunology and Microbiology business.industry Immunization Programs Vaccination Public Health Environmental and Occupational Health Rotavirus Vaccines Infant Acute gastroenteritis Rotavirus vaccine Gastroenteritis Hospitalization Infectious Diseases Socioeconomic Factors Child Preschool Acute Disease Molecular Medicine Immunization program Seasons business Sentinel Surveillance |
| Zdroj: | Vaccine |
| ISSN: | 1873-2518 |
| Popis: | BACKGROUND: Burkina Faso was one of the first African nations to introduce pentavalent rotavirus vaccine (RV5, RotaTeq) into its national immunization program in October 2013. We describe the impact and effectiveness of rotavirus vaccine on acute gastroenteritis (AGE) hospitalizations among Burkinabe children. METHODS: Sentinel hospital-based surveillance for AGE was conducted at four hospitals during December 2013 – February 2017. Demographic, clinical, and vaccination information was collected and stool specimens were tested by EIA. Trends in rotavirus AGE hospitalizations and changes in the proportion of AGE hospitalizations due to rotavirus were examined at two sentinel sites from January 2014 – December 2016. Unconditional logistic regression models using data from all 4 surveillance sites were used to calculate vaccine effectiveness (VE, defined as 1-odds ratio) by comparing the odds of vaccination among rotavirus AGE (cases) and non-rotavirus AGE (controls) patients, controlling for age, season, hospital site and socioeconomic factors. RESULTS: The proportion of AGE hospitalizations that tested positive for rotavirus declined significantly among children |
| Databáze: | OpenAIRE |
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