Seawater and freshwater challenges affect the insulin-like growth factors IGF-I and IGF-II in liver and osmoregulatory organs of the tilapia
| Autor: | Jean-François Baroiller, Giorgi Berishvili, Karl Link, Elisabeth Eppler, Natallia Shved, Manfred Reinecke, Helena D'Cotta |
|---|---|
| Přispěvatelé: | University of Zurich, Reinecke, M |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Gills
Salinity 1303 Biochemistry 10017 Institute of Anatomy medicine.medical_treatment Fresh Water Growth hormone receptor Kidney Biochemistry Intestin Insulin-like growth factor Insuline Salinité 0302 clinical medicine Endocrinology L52 - Physiologie animale - Croissance et développement Insulin-Like Growth Factor I Intestinal Mucosa Eau douce Facteur de croissance igf 0303 health sciences Tilapia Water-Electrolyte Balance 1310 Endocrinology Endocrinologie medicine.anatomical_structure Liver Organ Specificity Osmoregulation Foie medicine.medical_specialty food.ingredient 030209 endocrinology & metabolism 610 Medicine & health Osmorégulation Biology 03 medical and health sciences Paracrine signalling food Downregulation and upregulation Insulin-Like Growth Factor II Internal medicine medicine 1312 Molecular Biology Animals Seawater Adaptation Molecular Biology 030304 developmental biology Eau de mer Kidney metabolism Receptors Somatotropin Gène 11294 Institute of Evolutionary Medicine 570 Life sciences biology Sarotherodon melanotheron M12 - Production de l'aquaculture |
| Zdroj: | Molecular and Cellular Endocrinology |
| Popis: | Contradictory studies suggest IGF-I in fish liver and gills is involved in osmoregulation, but nothing is known about the kidney and intestine's role nor about IGF-II's role in any organ. Tilapia were transferred from freshwater (FW) to seawater (SW) for 1 week (wk) and retransferred to FW for another week. At 4 h, 1 d, 2 d, 3 d and 1wk after SW-transfer and FW-retransfer IGF-I, IGF-II and growth hormone receptor (GHR1) mRNA were measured by real-time PCR. Hepatic IGF-I, IGF-II and GHR1 mRNA were downregulated in parallel after SW-transfer, recovered and were again downregulated after FWretransfer. In gills, IGF-I, IGF-II andGHR1were upregulated synchronously after SW-transfer and, partially also after FW-retransfer. The renal genes were downregulated after SW-transfer and partially upregulated after FW-retransfer. Persisting upregulation in intestinal IGF-I mRNA occurred after FW-retransfer. Thus, endocrine and auto/paracrine IGF-I and IGF-II seem to be involved in fish osmoregulation in an organ-specific manner. = |
| Databáze: | OpenAIRE |
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