Hemodialysis in patients requiring 131I treatment for thyroid carcinoma
| Autor: | Francescaromana Festuccia, Laura Chiacchiararelli, Francesca Apponi, Francesco Scopinaro, Simona Barberi, Paolo Menè, Claudia Fofi, Giorgio Punzo |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Treatment outcome Biomedical Engineering Urology Medicine (miscellaneous) Bioengineering Radiation Dosage Iodine Radioisotopes Biomaterials Thyroid carcinoma Text mining Renal Dialysis Occupational Exposure medicine Carcinoma Humans In patient Thyroid Neoplasms Radiation Injuries business.industry General Medicine Middle Aged Ablation medicine.disease Treatment Outcome Kidney Failure Chronic Hemodialysis Occupational exposure business |
| Popis: | Purpose Thyroid malignancies can be treated by surgery followed by ablation of the remnant tissue with 131I. As iodide removal from the body occurs by renal extraction, in patients suffering from end-stage renal disease it is necessary to properly evaluate both timing and method of the extracorporeal treatment. Methods We present two patients on regular hemodialysis, admitted in isolation to the Nuclear Medicine Department and treated with 131I for thyroid carcinoma diagnosed during the check-up for transplantation. Both patients underwent two hemodialysis sessions with a portable machine for CRRT (continuous renal replacement therapy), 24 and 48 hours after the administration of 50 mCi of 131I. The nursing staff were monitored with a dosimeter. Radioactivity of the patients, dialysate and urines were measured during hemodialysis. Results The greater reduction was obtained with the first dialysis, but in both patients a further, though shorter, hemodialysis at 48 hours was necessary for reaching a patient's radioactivity compatible with discharge. Radioactivity measured in the dialysate demonstrated the almost total removal of radioiodine by dialysis alone. In both patients, follow-up exams revealed a complete ablation of thyroid tissue, without signs of local recurrence. The dose of radioactivity of the dialysis staff was below allowable limits. Conclusions We conclude that a successful reduction of radioactivity, without dispersing its therapeutic efficacy, can be obtained with daily hemodialysis with a CRRT machine in patients in isolation treated with 131I. A therapeutic model is proposed. |
| Databáze: | OpenAIRE |
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