RCVS–TCH score can predict reversible cerebral vasoconstriction syndrome in patients with thunderclap headache
Autor: | Chin-Sang Chung, Mi Ji Lee, Soohyun Cho, Young Eun Gil |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty Headache Disorders Primary Science Logistic regression Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans In patient 030212 general & internal medicine Derivation Prospective cohort study Retrospective Studies Thunderclap headaches Multidisciplinary business.industry Reproducibility of Results Middle Aged medicine.disease Reversible cerebral vasoconstriction syndrome Cerebrovascular Disorders Blood pressure Neurology Vasoconstriction Medicine Female Differential diagnosis business Neurological disorders 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Reversible cerebral vasoconstriction syndrome (RCVS) is one of the most important differential diagnosis in patients with thunderclap headache (TCH). We aimed to develop a new scoring system for RCVS in patients with TCH. We retrospectively analyzed 72 patients enrolled in the prospective study of TCH conducted in 2015–2016 (derivation set). We identified possible predictors for the diagnosis of RCVS and constructed a prediction model (RCVS–TCH score) using the multivariable logistic regression model. Diagnostic performance was validated to an independent validation set from our headache registry. The derivation set comprised 41 patients with RCVS and 31 with non-RCVS, and the validation set included 253 patients with TCH (165 with RCVS and 88 with non-RCVS). The RCVS–TCH score (range: 0–12) contained four predictors: recurrent TCHs, female sex, triggering factor for TCH (single or multi) and blood pressure surge. The C-index of RCVS–TCH score was 0.929 (95% CI = 0.874–0.984). The RCVS–TCH score ≥ 7 had a sensitivity of 80% and a specificity of 97% in discriminating RCVS from non-RCVS. In the validation set, RCVS–TCH score showed a C-index of 0.861 (95% CI = 0.815–0.908). In our study, the RCVS–TCH showed good performance, which may aid the diagnosis of RCVS among patients with TCH. |
Databáze: | OpenAIRE |
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