Assessment of diagnosis of inflammatory breast cancer cases at two cancer centers in E gypt and T unisia
| Autor: | Samir Khalafallah, Catherine Schairer, Sandra M. Swain, Saad Eissa, Sherif Omar, Farhat Ben Ayed, Elizabeth D. Kantor, Wided Ben Ayoub, Amr S. Soliman, Hussein M. Khaled, Linda Morris Brown, Mitchell H. Gail, Sofia D. Merajver |
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| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty Delayed Diagnosis Tunisia Locally advanced peau d'orange Inflammatory breast cancer Diagnosis Differential Breast cancer Oncology Service Hospital Internal medicine Clinical information medicine Humans Edema Peau d'orange Radiology Nuclear Medicine and imaging Medical diagnosis skin and connective tissue diseases business.industry Clinical Cancer Research Cancer medicine.disease Surgery Oncology Egypt Female Inflammatory Breast Neoplasms Differential diagnosis medicine.symptom inflammatory breast cancer business erythema |
| Zdroj: | Cancer Medicine |
| ISSN: | 2045-7634 |
| DOI: | 10.1002/cam4.48 |
| Popis: | The diagnosis of inflammatory breast cancer (IBC) is largely clinical and therefore inherently somewhat subjective. The objective of this study was to evaluate the diagnosis of IBC at two centers in North Africa where a higher proportion of breast cancer is diagnosed as IBC than in the United States (U.S.). Physicians prospectively enrolled suspected IBC cases at the National Cancer Institute (NCI) – Cairo, Egypt, and the Institut Salah Azaiz (ISA), Tunisia, recorded extent and duration of signs/symptoms of IBC on standardized forms, and took digital photographs of the breast. After second-level review at study hospitals, photographs and clinical information for confirmed IBC cases were reviewed by two U.S. oncologists. We calculated percent agreement between study hospital and U.S. oncologist diagnoses. Among cases confirmed by at least one U.S. oncologist, we calculated median extent and duration of signs and Spearman correlations. At least one U.S. oncologist confirmed the IBC diagnosis for 69% (39/50) of cases with photographs at the NCI-Cairo and 88% (21/24) of cases at the ISA. All confirmed cases had at least one sign of IBC (erythema, edema, peau d'orange) that covered at least one-third of the breast. The median duration of signs ranged from 1 to 3 months; extent and duration of signs were not statistically significantly correlated. From the above-mentioned outcomes, it can be concluded that the diagnosis of a substantial proportion of IBC cases is unambiguous, but a subset is difficult to distinguish from other types of locally advanced breast cancer. Among confirmed cases, the extent of signs was not related to delay in diagnosis. |
| Databáze: | OpenAIRE |
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