The effect of zolpidem on cognitive function and postural control at high altitude

Autor: Karen Davranche, Pierre Bouzat, Samuel Verges, Pauline Manhes, Paul Robach, Fancesco Botrè, Xavier de la Torre, Monica Mazzarino, Guillaume Sechaud, Sébastien Baillieul, Pierre Banco, Laurence Casini
Přispěvatelé: Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de psychologie cognitive (LPC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes (UGA), CHU Grenoble, Hypoxie et physiopathologies cardiovasculaire et respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire HP2, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
cognition
Sleepiness
Pyridines
Altitude Sickness
hypnotics
law.invention
Placebos
Hypnotic
0302 clinical medicine
Randomized controlled trial
law
Sleep Initiation and Maintenance Disorders
030212 general & internal medicine
ComputingMilieux_MISCELLANEOUS
Cross-Over Studies
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
musculoskeletal
neural
and ocular physiology
Effects of high altitude on humans
Anesthesia
[SCCO.PSYC]Cognitive science/Psychology
Female
psychological phenomena and processes
altitude
hypoxia
sleep
medicine.drug
Adult
Elementary cognitive task
Zolpidem
medicine.drug_class
Posture
Disorders of Excessive Somnolence
Placebo
03 medical and health sciences
Double-Blind Method
Physiology (medical)
Reaction Time
medicine
Humans
Wakefulness
Adverse effect
business.industry
[SCCO.NEUR]Cognitive science/Neuroscience
Crossover study
Sleep Aids
Pharmaceutical
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Sleep
Sleep, 2018, 41 (10)
SLEEP
SLEEP, 2018, 41 (10), ⟨10.1093/sleep/zsy153⟩
ISSN: 0161-8105
1550-9109
Popis: Study Objectives: Sleep is altered at high altitude leading many mountaineers to use hypnotics in order to improve sleep efficiency. While after a full night at altitude the short-acting hypnotic zolpidem does not appear to alter cognitive function, residual adverse effects should be considered following early waking-up as performed by mountaineers. We hypothesized that zolpidem intake at high altitude would alter cognitive function 4 hours after drug intake. Methods: In a randomized double-blind controlled cross-over study, 22 participants were evaluated during two nights at sea level and two nights at 3800 m, 4 hours after zolpidem (10 mg) or placebo intake at 10:00 pm. Polygraphic recording was performed until waking-up at 01:30 am. Sleep quality, sleepiness and symptoms of acute mountain sickness were assessed by questionnaires. Two cognitive tasks (Simon task and durationproduction task) were performed at rest and during exercise and postural control was evaluated. Results: Zolpidem increased reaction time in all conditions (zolpidem 407 +/- 9 ms vs. placebo 380 +/- 11 ms; p < 0.001) and error rate in incongruent trials only (10.2 +/- 1.1% vs. 7.8 +/- 0.8%; p < 0.01) in the Simon task and increased time perception variability (p < 0.001). Zolpidem also altered postural parameters (e. g. center of pressure area, zolpidem 236 +/- 171.5 mm(2) vs. placebo 119.6 +/- 59 mm(2); p < 0.001). Zolpidem did not affect apnea-hypopnea index and mean arterial oxygen saturation (p > 0.05) but increased sleep quality (p < 0.001). Zolpidem increased symptoms of acute mountain sickness and sleepiness (p < 0.05). Conclusions: Acute zolpidem intake at high altitude alters cognitive functions and postural control during early wakening which may be deleterious for safety and performances of climbers.
Databáze: OpenAIRE
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