Neurological injury during cardiopulmonary bypass in the rat
| Autor: | H P, Grocott, G B, Mackensen, M F, Newman, D S, Warner |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Neurology Neurological injury Neuroprotection Body Temperature 030218 nuclear medicine & medical imaging law.invention Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine law Small animal Cardiopulmonary bypass medicine Animals Radiology Nuclear Medicine and imaging Advanced and Specialized Nursing Cardiopulmonary Bypass business.industry Equipment Design General Medicine Rats Cardiac surgery surgical procedures operative Anesthesia Models Animal Brain Damage Chronic Cardiology and Cardiovascular Medicine business Complication Safety Research Perfusion Echocardiography Transesophageal Psychomotor Performance 030217 neurology & neurosurgery circulatory and respiratory physiology |
| Zdroj: | Perfusion. 16:75-81 |
| ISSN: | 1477-111X 0267-6591 |
| DOI: | 10.1177/026765910101600111 |
| Popis: | Cerebral injury is a well-known complication of cardiac surgery. Investigations of both injury mechanisms and neuroprotective strategies have partially been limited by the lack of an adequate preclinical model of small animal cardiopulmonary bypass (CPB). We sought to determine if neurological injury could be demonstrated in a recovery model of complete CPB in the rat. Rats ( n = 5) underwent 45 min of normothermic CPB followed by 24 h of recovery. Compared to sham-operated rats ( n = 5), the CPB group showed a worse neurological outcome score (median, 25-75th percentile) compared to controls (5, 4-7 vs 9, 8-9, p = 0.016). This rat model of CPB may allow for the study of CPB-associated neurological injury. |
| Databáze: | OpenAIRE |
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