Prevalence of Mycoplasma genitalium Infection, Antimicrobial Resistance Mutations, and Symptom Resolution Following Treatment of Urethritis
| Autor: | Candice J. McNeil, Noelle Myler, Stephanie N. Taylor, Lisa E. Manhart, Lori M Newman, Arlene C. Seña, Harold C. Wiesenfeld, William M. Geisler, Katherine E. Bowden, Laura H. Bachmann, Robert D. Kirkcaldy, Rachael Fuchs |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Microbiology (medical) Sexually transmitted disease MG infection medicine.medical_specialty Mycoplasma genitalium Azithromycin Antibiotic resistance Internal medicine Drug Resistance Bacterial Prevalence Humans Medicine Mycoplasma Infections Urethritis Online Only Articles biology business.industry biology.organism_classification medicine.disease Confidence interval Anti-Bacterial Agents Geographic distribution Infectious Diseases Mutation Female Macrolides business medicine.drug |
| Zdroj: | Clin Infect Dis |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciaa293 |
| Popis: | Background Antimicrobial resistance in Mycoplasma genitalium (MG), a cause of urethritis, is a growing concern. Yet little is known about the geographic distribution of MG resistance in the United States or about its associated clinical outcomes. We evaluated the frequency of MG among men with urethritis, resistance mutations, and posttreatment symptom persistence. Methods We enrolled men presenting with urethritis symptoms to 6 US sexually transmitted disease (STD) clinics during June 2017–July 2018; men with urethritis were eligible for follow-up contact and, if they had persistent symptoms or MG, a chart review. Urethral specimens were tested for MG and other bacterial STDs. Mutations in 23S ribosomal ribonucleic acid (rRNA) loci (macrolide resistance–associated mutations [MRMs]) and in parC and gyrA (quinolone-associated mutations) were detected by targeted amplification/Sanger sequencing. Results Among 914 evaluable participants, 28.7% (95% confidence interval [CI], 23.8–33.6) had MG. Men with MG were more often Black (79.8% vs 66%, respectively), Conclusions MG infection was common among men with urethritis; the MRM prevalence was high among men with MG. Persistent symptoms following treatment were frequent among men both with and without MG. |
| Databáze: | OpenAIRE |
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