Neonatal Antiepileptic Medication Treatment Patterns: A Decade of Change
| Autor: | Hibo H. Abdi, Lina Yossef, Laurel A. Slaughter, Jonathan L. Slaughter, Pablo J. Sánchez, Patricia B. Reagan, Angela Firestine, Vi T. Le |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Levetiracetam Databases Factual medicine.medical_treatment Gestational Age Article 03 medical and health sciences symbols.namesake 0302 clinical medicine Seizures 030225 pediatrics medicine Humans Poisson regression Neonatal seizure Cerebral Intraventricular Hemorrhage Retrospective Studies business.industry Infant Newborn Obstetrics and Gynecology Confidence interval United States Stroke Anticonvulsant Relative risk Phenobarbital Pediatrics Perinatology and Child Health Cohort Hypoxia-Ischemia Brain symbols Anticonvulsants Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Am J Perinatol |
| ISSN: | 1098-8785 |
| Popis: | Objective This study aims to describe the frequency and characteristics of anticonvulsant medication treatments initiated in the neonatal period. Study Design We analyzed a cohort of neonates with a seizure diagnosis who were discharged from institutions in the Pediatric Health Information System between 2007 and 2016. Adjusted risk ratios and 95% confidence intervals for characteristics associated with neonatal (≤ 28 days postnatal) anticonvulsant initiation were calculated via modified Poisson regression. Results A total of 6,245 infants from 47 institutions were included. There was a decrease in both phenobarbital initiation within the neonatal period (96.9 to 91.3%, p = 0.015) and continuation at discharge (90.6 to 68.6%, p Conclusion Phenobarbital remains the most widely used neonatal seizure treatment. Levetiracetam is increasingly used as a second line therapy. Increasing levetiracetam use indicates a need for additional study to determine its effectiveness in reducing seizure burden and improving long-term outcomes. |
| Databáze: | OpenAIRE |
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