Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense
| Autor: | Vichai Reutrakul, Sakchai Hongthong, Narong Nuntasaen, Pawinee Piyachaturawat, Thaworn Jaipetch, Chutima Kuhakarn, Surawat Jariyawat |
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| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
biology Molecular Structure Chemistry Stereochemistry Alkaloid Ethyl acetate Annonaceae Plant Science General Medicine Fractionation biology.organism_classification Antineoplastic Agents Phytogenic Dasymaschalon sootepense chemistry.chemical_compound Alkaloids Complementary and alternative medicine Cell Line Tumor Drug Discovery Cytotoxic T cell Animals Humans Aporphine Cytotoxicity |
| Zdroj: | Natural product communications. 9(7) |
| ISSN: | 1934-578X |
| Popis: | Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1–2 and 5–6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines. |
| Databáze: | OpenAIRE |
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