Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies
| Autor: | Robyn J, Barst, Kamal K, Mubarak, Roberto F, Machado, Kenneth I, Ataga, Raymond L, Benza, Oswaldo, Castro, Robert, Naeije, Namita, Sood, Paul S, Swerdlow, Mariana, Hildesheim, Mark T, Gladwin, M, Telen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac output congenital hereditary and neonatal diseases and abnormalities Hypertension Pulmonary Anemia Sickle Cell Pulmonary Artery Article Double-Blind Method Internal medicine medicine.artery hemic and lymphatic diseases Medicine Humans Antihypertensive Agents Sulfonamides Exercise Tolerance business.industry Respiratory disease Central venous pressure Hemodynamics Bosentan Hematology Middle Aged medicine.disease Pulmonary hypertension Surgery medicine.anatomical_structure Pulmonary artery Vascular resistance Cardiology Exercise Test Pulmonary venous hypertension Female Vascular Resistance business medicine.drug |
| Zdroj: | British journal of haematology. 149(3) |
| ISSN: | 1365-2141 |
| Popis: | Doppler-defined pulmonary hypertension (PH) in sickle cell disease (SCD) is associated with 40% mortality at 40 months. To assess the effect of bosentan in SCD-PH, two randomized, double-blind, placebo-controlled, 16-week studies were initiated. Safety concerns are particularly relevant in SCD due to comorbid conditions. ASSET-1 and -2 enrolled patients with pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PH), respectively. Haemodynamics and 6-min walk distance (6MWD) were obtained at baseline and week 16. The studies were terminated due to slow site initiation and patient enrolment (n = 26). Bosentan appeared to be well tolerated. Although sample sizes were limited, in ASSET-1 at baseline, 6MWD correlated with cardiac output (CO; P = 0.006) with non-significant inverse correlations between 6MWD and pulmonary vascular resistance (PVR; P = 0.07) and between 6MWD and right atrial pressure (P = 0.08). In ASSET-2 at baseline, there was a non-significant correlation between 6MWD and CO (P = 0.06). Due to limited sample sizes, efficacy endpoints were not analysed. However, in both studies, non-significant increases in CO were observed with bosentan compared to placebo. Similarly, non-significant decreases in PVR were observed with bosentan. Limited data in SCD-PH suggest that a low 6MWD predicts a low CO. Standard-dose bosentan appears to be well tolerated. Further investigation is warranted. Clinicaltrials.gov registration numbers NCT00310830, NCT00313196, NCT00360087. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text