| Autor: |
Creemers, A., van der Zalm, A. P., van de Stolpe, A., Holtzer, L., Stoffels, M., Hooijer, G. K. J., Ebbing, E. A., van Ooijen, H., van Brussel, A. G. C., Aussems-Custers, E. M. G., van Berge Henegouwen, M. I., Hulshof, M. C. C. M., Bergman, J. J. G. H. M., Meijer, S. L., Bijlsma, M. F., van Laarhoven, H. W. M. |
| Rok vydání: |
2022 |
| DOI: |
10.6084/m9.figshare.19656845.v1 |
| Popis: |
Additional file 1: Figure S1. Poor responder phenotype in patient samples. A Pathway signal transduction activity of six key signal transduction pathways was measured in the resectable disease cohort (i). Pre-treatment biopsy pathway activity scores were subtracted from all matched resections that both passed QC, i.e. delta activity score (N = 69). Two-sided Wilcoxon signed-rank statistical tests were performed between all post-nCRT (N = 56) and surgery only (N = 13) patients. p-values are indicated in the figures. Boxplots represent median with interquartile range. B All post-nCRT resection specimens from the resectable disease cohort were assessed for correlations between FOXO and TGF-β activity. Spearman correlations were performed, N = 138, separated for low (1–2, N = 17, all Mandard 2), middle (3, N = 59) and high (4–5, N = 47) Mandard score. C Pre-treatment biopsies were assessed for correlations between FOXO and TGF-β activity. Spearman correlations were performed, N = 77, separated for low (1–2, N = 22), middle (3, N = 37) and high (4–5, N = 18) Mandard score obtained after nCRT. D Disease free survival of patients with combined low FOXO and TGF-β pathway activity versus combined high pathway activities in post-nCRT resection specimens (N = 83). Cut-off by median pathway activity score. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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