TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity
| Autor: | Maria Elizabeth Rossi da Silva, Rosa Ferreira dos Santos, Maria do Carmo Arruda-Marques, Mari Cassol Ferreira, Rosa Tsuneshiro Fukui |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Glucose metabolism disorders 030209 endocrinology & metabolism Polymorphism genetic Glucagon 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus Type 2 diabetes mellitus Internal Medicine Medicine lcsh:RC620-627 Proinsulin business.industry Insulin Research nutritional and metabolic diseases medicine.disease lcsh:Nutritional diseases. Deficiency diseases 030104 developmental biology Endocrinology Postprandial Homeostatic model assessment Polymorphism single nucleotide business TCF7L2 Hyperglycemia postprandial |
| Zdroj: | Diabetology & Metabolic Syndrome Diabetology & Metabolic Syndrome, Vol 10, Iss 1, Pp 1-7 (2018) |
| ISSN: | 1758-5996 |
| Popis: | Background The TCF7L2 rs7903146 variant is strongly associated with type 2 diabetes mellitus (T2DM). However, the mechanisms involved in this association remain unknown and may include extrapancreatic effects. The aim of this study was to perform a metabolic characterization of T2DM patients with and without the TCF7L2 rs7903146 risk T allele and analyze some influences of the TCF7L2 genotype on glucose metabolism. Methods Patients with T2DM (n = 162) were genotyped for the TCF7L2 rs7903146 single nucleotide polymorphism. Individuals with CT/TT and CC genotypes were compared regarding basal serum levels of glucose, glycosylated hemoglobin A1C, HDL, uric acid, insulin, and C-peptide. A subset of 56 individuals was evaluated during a 500-calorie mixed-meal test with measurements of glucose, insulin, proinsulin, C-peptide and glucagon. Additional secondary assessments included determination of insulinogenic index (IGI30), and insulin sensitivity (%S) and resistance (IR) by Homeostatic model assessment (HOMA). Results Patients with the CT/TT genotype showed lower baseline plasma concentrations of C-peptide when compared with those with the CC genotype. Of the 56 individuals who participated in the mixed-meal test, 26 and 30 had the CC and CT/TT genotypes, respectively. CT/TT subjects, compared with CC individuals, had higher post prandial plasma levels of insulin and C-peptide at 30–120 min (p |
| Databáze: | OpenAIRE |
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