Campomanesia sp. flour attenuates non-alcoholic fatty liver disease on rats fed with a hypercaloric diet
| Autor: | Vitória Helena de Oliveira Teixeira Reis, Cynthia Monteiro Santee, Paulo Sergio Loubet Filho, Matheus Pereira da Costa, Camila Jordão Cândido, Thayná Gil Santos, Luciane Candeloro Portugal, Wander Fernando de Oliveira Filiú, Elisvânia Freitas dos Santos |
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| Rok vydání: | 2019 |
| Předmět: |
Male
040301 veterinary sciences Myrtaceae Microvesicular Steatosis Campomanesia Weight Gain 0403 veterinary science chemistry.chemical_compound Food Animals Non-alcoholic Fatty Liver Disease medicine Animals Food science Rats Wistar IC50 biology Chemistry Cholesterol Metabolic disorder Fatty liver 0402 animal and dairy science 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 040201 dairy & animal science Obesity Animal Feed Diet Rats Complementation Liver Animal Science and Zoology Energy Intake Energy Metabolism |
| Zdroj: | Journal of animal physiology and animal nutritionREFERENCES. 104(5) |
| ISSN: | 1439-0396 |
| Popis: | Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder caused by excess consumption of hypercaloric foods. Guavira (Campomanesia sp.) pulp has broad technological applicability, yet the peel and seeds are considered industrial residue. The objective of this unprecedented study was to evaluate the effects of the flour from guavira's industrial residue (GF) consumption in rats fed with hypercaloric diet (HD). During 65 days, 50 rats were separated into a control group: 1%, 2%, 4% and 8% HD with GF complementation in the diet. The GF chemical composition, phenolic compounds, antioxidant capacity, serum biochemical parameters (glucose, cholesterol, HDL, non-HDL, triglycerides, AST, ALT, and oral glucose tolerance test), fat liver content, and hepatic histomorphology had been characterized. GF is mainly composed of fibres, with phenolic content of 7,391.09 mg AGE/100 g GF and relevant antioxidant capacity (IC50 2.22 and ORAC 155.68 μmol/TE g-1 ). Serum biochemical analysis did not differ statistically (except ALT reduction, p < .05). Fat liver content was smaller on HD2%GF (p < .0001). The control group and 1% GF showed greater diffuse microvesicular steatosis compared to the other groups when using hepatic morphological analysis (p < .05). GF consumption attenuated NAFLD caused by a hypercaloric diet, and this effect may be related to the fibre content and bioactive compounds in GF. |
| Databáze: | OpenAIRE |
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