Activity of the alternative complement pathway after splenectomy: comparison to activity in sickle cell disease and hypogammaglobulinemia
| Autor: | Rutherford B. Polhill, S. Randolph Edmonds, Richard B. Johnston, James M. Corry |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Adolescent Anemia medicine.medical_treatment Spherocytosis Splenectomy Complement Pathway Alternative Immunoglobulins Disease Anemia Sickle Cell Spherocytosis Hereditary Hypogammaglobulinemia Agammaglobulinemia Medicine Humans Child Complement Activation biology business.industry Infant Complement C3 Middle Aged medicine.disease Complement system Purpura Thrombocytopenic Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Alternative complement pathway Immunologic Techniques Female Antibody business |
| Zdroj: | The Journal of pediatrics. 95(6) |
| ISSN: | 0022-3476 |
| Popis: | Patients with sickle cell disease and individuals who have undergone splenectomy share defects of certain host defense mechanisms and a predisposition to severe pyogenic bacterial infections. Since patients with sickle cell disease can have deficient activity of the alternative complement pathway, we have tested such activity in sera from splenectomized children and adults. A new kinetic hemolytic assay has been used, and we have compared results to those obtained with sera from patients with sickle cell disease or hypogammaglobulinemia. Sera from six of 58 splenectomized individuals (10%). had defective function of the alternative pathway, compared to 10 of 62 sera from patients with sickle cell disease (16%) and 10 of 18 sera from hypogammaglobulinemic patients (56%). Deficiency of antibody, a rate-influencing component of alternative pathway activity in this system, appears responsible for deficient activity in the hypogammaglobulinemic sera. The molecular basis for the deficiency found in sickle cell disease or after splenectomy is not clear. Defective function of the alternative complement pathway could contribute to the increased predisposition to bacterial infection that exists in these three patient groups. |
| Databáze: | OpenAIRE |
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