Early-Life Growth and Benign Breast Disease
| Autor: | Lauren C. Houghton, Karin B. Michels, Mary Beth Terry, Julie D. Flom, Barbara A. Cohn, Ying Wei, Piera M. Cirillo, Mandy Goldberg |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Epidemiology Original Contributions Birth weight Mothers Growth Weight Gain Logistic regression Body Mass Index Breast Diseases Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer 030225 pediatrics medicine Birth Weight Body Size Humans Prospective Studies skin and connective tissue diseases Obstetrics business.industry Infant Odds ratio medicine.disease Confidence interval Child Preschool 030220 oncology & carcinogenesis Breast disease medicine.symptom business Weight gain Body mass index |
| Zdroj: | Am J Epidemiol |
| ISSN: | 1476-6256 0002-9262 |
| Popis: | Using prospective data from the Early Determinants of Mammographic Density study (United States, 1959–2008, n = 1121), we examined the associations between maternal body size, birth size, and infant and early childhood growth during 3 time periods (0–4 months, 4–12 months, and 1–4 years) and benign breast disease (BBD) using multivariable logistic regression with generalized estimating equations. A total of 197 women (17.6%) reported receiving a diagnosis of BBD by a physician. Higher body mass index at age 7 years was inversely associated with BBD risk. Rapid weight gain from age 1 year to 4 years, defined as an increase of least 2 major percentiles (e.g., 5th, 10th, 25th, 50th, 75th, and 95th) relative to stable growth, defined as remaining within 2 percentiles, was also inversely associated with BBD (odds ratio (OR) = 0.51, 95% confidence interval (CI): 0.23, 1.15). In contrast, rapid weight gain in infancy was positively associated with BBD relative to stable growth (from 0 to 4 months, OR = 1.65, 95% CI: 1.04, 2.62; from 4 to 12 months, 1.85, 95% CI: 0.89, 3.85), independent of birth weight, which was not associated with BBD. Our results suggest that patterns of early-life weight gain are important to BBD risk. Thus, susceptibility to BBD, like susceptibility to breast cancer, might start in early life. |
| Databáze: | OpenAIRE |
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