Improved Synthesis of α-Glycerol Monolaurate Using Lipozyme TL IM
| Autor: | Febri Odel, Nitbani, Lidia Sthivany, Angwarmasse, Erwin Yohanes, Bessy, Hermania Em, Wogo, Annytha Ina Rohi, Detha, Putra Jiwamurwa Pama, Tjitda |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Oleo Science. 71:1013-1020 |
| ISSN: | 1347-3352 1345-8957 |
| DOI: | 10.5650/jos.ess21312 |
| Popis: | This study aimed to synthesize α-Glycerol Monolaurate from protected glycerol (glycerol 1,2-acetonide) using Lipozym TL IM as a catalyst. In the first step, transesterification of methyl laurate and glycerol 1,2-acetonide with Lipozyme TL IM produced 1,2-acetonide-3-lauryl glycerol. In the second step, deprotection of 1,2-acetonide-3-lauryl glycerol with Amberlyst-15 produced α-Glycerol Monolaurate. Furthermore, the optimum yield (82.1%) of 1,2-acetonide-3-lauryl glycerol (light yellow liquid, purity of 92%) was achieved at a reactant mole ratio of 1, n-hexane (4 mL) with a reaction time of 12 hours, and total Lipozyme TL IM of 5% (w/w of the total weight of reactants) at a temperature of 35°C. Deprotection of 1,2-acetonide-3-lauryl glycerol with Amberlyst-15 was conducted at room temperature for 24 hours. At a melting point of 62.8°C, and purity of 100% α-Glycerol Monolaurate in the form of a white solid was obtained with a yield of 74.6% after the recrystallization of the crude product. This α-glycerol monolaurate synthesis reaction pathway can be referred to as a green α-monoacylglyceride synthesis method. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|