Acute inhalation toxicity study of n-heneicosane and its combination with diflubenzuron: An attracticide of Aedes aegypti
| Autor: | Deeksha Singh, Anshoo Gautam, Peeyush Shrivastava, Rajagopalan Vijayaraghavan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Health Toxicology and Mutagenesis Aedes aegypti 010501 environmental sciences Biology Pharmacology Kidney Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Aedes Alkanes Insect growth regulator Animals Particle Size Rats Wistar Lung 0105 earth and related environmental sciences Inhalation exposure Inhalation Exposure Inhalation Nebulizers and Vaporizers Respiration Public Health Environmental and Occupational Health Heart Organ Size biology.organism_classification Rats 030104 developmental biology Diflubenzuron Liver chemistry Insect Repellents Toxicity Pheromone Spleen |
| Zdroj: | Toxicology and Industrial Health. 34:703-713 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233718774987 |
| Popis: | Objective: Combination of an oviposition pheromone and an insect growth regulator for the control of vectors is an effective approach. There is a need for toxicological evaluation before its introduction. The present study evaluates the acute inhalation toxicity of n-heneicosane and its combination with diflubenzuron in a head-only inhalation exposure chamber made of glass. Materials and methods: A head-only inhalation exposure chamber made of glass (volume: 3.5 l) was used for exposing four rats at a time. A glass nebulizer was used for aerosolization of n-heneicosane and its combination with diflubenzuron (1:10 w/w). Nebulization pressure was 10 and 15 psi and the air flow of exposure the chamber was adjusted to 30 lpm. Male Wistar rats were acclimatized in whole body plethysmographs that were connected to volumetric flow pressure transducers by silicon tubes. The transducers were connected to an amplifier and a digitized response was recorded through an oscillograph and personal computers. Respiratory variables were recorded online. After inhalation exposure, various other parameters like survival, body weight, organ body weight index and biochemical changes were recorded for analysis. Results and discussion: Particle size determination proved that the aerosol particles were within the respirable range. LC50 of n-heneicosane and its combination with diflubenzuron was found to be more than 5 g/m3. There were minimal changes observed during exposure to n-heneicosane and also its combination with diflubenzuron on the respiratory variables. The changes were not consistent with the dose. Conclusion: n-Heneicosane and its combination with diflubenzuron showed low mammalian toxicity. |
| Databáze: | OpenAIRE |
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