Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion

Autor: Akihiro Miyazaki, Tomoko Sonoda, Hironari Dehari, Tomohiro Igarashi, Takeshi Kaneko, Jun-ichi Kobayashi, Kazuhiro Ogi, Akira Miyakawa, Shota Shimizu, Kazushige Koike, Hiroyoshi Hiratsuka, Tadashi Hasegawa, Megumi Ueda
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Oncology
Topography
Lymphovascular invasion
medicine.medical_treatment
Perineural invasion
Cancer Treatment
lcsh:Medicine
Kaplan-Meier Estimate
Metastasis
0302 clinical medicine
Basic Cancer Research
Medicine and Health Sciences
Neoplasm Metastasis
lcsh:Science
Aged
80 and over
Islands
Multidisciplinary
Invasive Tumors
Squamous Cell Carcinomas
Middle Aged
Prognosis
Primary tumor
Immunohistochemistry
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Mouth Neoplasms
Anatomy
Research Article
Adult
medicine.medical_specialty
Carcinomas
Lymphatic System
03 medical and health sciences
Tumor budding
Diagnostic Medicine
Internal medicine
medicine
Carcinoma
Cancer Detection and Diagnosis
Humans
Neoplasm Invasiveness
Aged
Proportional Hazards Models
Retrospective Studies
Landforms
business.industry
lcsh:R
Cancer
Cancers and Neoplasms
Biology and Life Sciences
Neck dissection
Geomorphology
medicine.disease
030104 developmental biology
Logistic Models
Multivariate Analysis
Earth Sciences
lcsh:Q
Lymph Nodes
Neoplasm Grading
business
Follow-Up Studies
Zdroj: PLoS ONE, Vol 13, Iss 4, p e0195451 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Pathologically proven regional lymph node metastasis affects the prognosis in early stage oral cancer. Therefore we investigated invasive tumor patterns predicting nodal involvement and survival in patients with clinically node-negative T1 and T2 oral squamous cell carcinoma (cT1,2N0M0 OSCC). Ninety-one cases of cT1,2N0M0 OSCC treated with transoral resection of the primary tumor were assessed based on 3 types of invasive tumor patterns on histopathologic and pancytokeratin-stained immunohistological sections: the mode of invasion, worst pattern of invasion (WPOI), and tumor budding. The correlations among invasive tumor patterns, regional metastasis, and disease-free survival were analyzed. Of the 91 cases, 22 (24%) had pathologically proven regional metastasis. The mode of invasion (p
Databáze: OpenAIRE
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