Virulence Factors of Helicobacter pylori: A Review
| Autor: | Elizabeth Maria Afonso Rabelo-Gonçalves, Bruna Maria Roesler, José Murilo Robilotta Zeitune |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Helicobacter pylori
peptic ulcer disease biology business.industry Stomach virulence factors Gastroenterology Virulence Chronic gastritis Cancer Review Disease medicine.disease Bioinformatics biology.organism_classification digestive system diseases Lymphoma medicine.anatomical_structure chronic gastritis Immunology medicine Gastric mucosa gastric adenocarcinoma business |
| Zdroj: | Clinical Medicine Insights. Gastroenterology |
| ISSN: | 1179-5522 |
| DOI: | 10.4137/cgast.s13760 |
| Popis: | Helicobacter pylori is a spiral-shaped Gram-negative bacterium that colonizes the human stomach and can establish a long-term infection of the gastric mucosa, a condition that affects the relative risk of developing various clinical disorders of the upper gastrointestinal tract, such as chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. H. pylori presents a high-level of genetic diversity, which can be an important factor in its adaptation to the host stomach and also for the clinical outcome of infection. There are important H. pylori virulence factors that, along with host characteristics and the external environment, have been associated with the different occurrences of diseases. This review is aimed to analyzing and summarizing the main of them and possible associations with the clinical outcome. |
| Databáze: | OpenAIRE |
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