Ni‐Catalyzed Cyclization of Enynes and Alkynylboronates: Atom‐Economical Synthesis of Boryl‐1,4‐dienes
| Autor: | Diego J. Cárdenas, Natalia Cabrera-Lobera, M. Teresa Quirós, Elena Buñuel |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Reaction mechanism 010405 organic chemistry Chemistry Ligand Organic Chemistry chemistry.chemical_element Salt (chemistry) Homogeneous catalysis One-Step General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Nickel chemistry.chemical_compound Phosphine |
| Zdroj: | Chemistry – A European Journal. 25:14512-14516 |
| ISSN: | 1521-3765 0947-6539 |
| DOI: | 10.1002/chem.201903405 |
| Popis: | We report a novel atom-economical Ni-catalyzed cyclization reaction of enynes with alkynylboronates. The reaction employs a non-expensive Ni salt, a phosphine-based ligand and easy-handling alkynylboronates as boron-carbon source. The reaction provides complex fused-bicyclic compounds containing borylated 1,4-cyclohexadienes in high yields in short reaction times, involving the formation of two C-C bonds in one step. A reasonable reaction mechanism is proposed based on mechanistic experimental results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |