Effect of lurasidone treatment on chronic mild stress-induced behavioural deficits in male rats: The potential role for glucocorticoid receptor signalling
| Autor: | Mariusz Papp, Monika Niemczyk, Piotr Gruca, Marco A. Riva, Ewa Litwa, Francesca Calabrese, Paola Brivio, Magdalena Lason, Giulia Sbrini |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Anhedonia Gene Expression Hippocampus Lurasidone Hydrochloride 03 medical and health sciences Receptors Glucocorticoid 0302 clinical medicine Glucocorticoid receptor Mild stress Internal medicine Male rats medicine Animals Cognitive Dysfunction Pharmacology (medical) Rats Wistar 030304 developmental biology Lurasidone Pharmacology 0303 health sciences Behavior Animal business.industry Recognition Psychology Recovery of Function Rats Psychiatry and Mental health Endocrinology Signalling Mood Chronic Disease Serotonin 5-HT2 Receptor Antagonists business Stress Psychological 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 34:420-428 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881119895547 |
| Popis: | Background: Stress represents one of the main precipitating factors for psychiatric diseases, characterised by an altered function of glucocorticoid receptors (GR), known to play a role in mood and cognitive function. We investigated the ability of the antipsychotic lurasidone to modulate the involvement of genomic and non-genomic GR signalling in the behavioural alterations due to chronic stress exposure Methods: Male Wistar rats were exposed to seven weeks of chronic mild stress (CMS) and treated with lurasidone (3 mg/kg/day) starting from the second week of stress for more five weeks. Gene expression and protein analyses were conducted in dorsal hippocampus. Results: Seven weeks of CMS induced anhedonia and cognitive impairment, which were normalised by lurasidone. At molecular level, CMS rats showed an increase of GR protein levels by 60% ( pConclusion: Our results further support the role of glucocorticoid signalling in the dysfunction associated with stress exposure. We provide novel insights on the mechanism of lurasidone, suggesting its effectiveness on different domains associated with psychiatric disorders. |
| Databáze: | OpenAIRE |
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