Limited Role for C. pneumoniae, CMV and HSV-1 in Cerebral Large and Small Vessel Atherosclerosis
| Autor: | M Voorend, Cathrien A. Bruggeman, B. Kubat, A.J.A.M. van der Ven, Jan Lodder |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty small vessel disease Infectious diseases and international health [NCEBP 13] Cerebral arteries brain Cytomegalovirus medicine.disease_cause Article medicine.artery Chlamydia pneumoniae Parenchyma Basilar artery medicine business.industry Leukoaraiosis Poverty-related infectious diseases [N4i 3] Hyperintensity Pathogenesis and modulation of inflammation [N4i 1] Psychiatry and Mental health Herpes simplex virus Neurology Middle cerebral artery Immunohistochemistry Neurology (clinical) Microbial pathogenesis and host defense [UMCN 4.1] Herpes Simplex Virus type 1 business Infection and autoimmunity [NCMLS 1] |
| Zdroj: | The Open Neurology Journal Open Neurology Journal, 2, 39-44 Open Neurology Journal, 2, pp. 39-44 |
| ISSN: | 1874-205X |
| Popis: | Contains fulltext : 69494.pdf (Publisher’s version ) (Open Access) Aims: To explore whether Chlamydia pneumoniae, Cytomegalovirus and Herpes Simplex Virus type 1 could be detected in large and small cerebral arteries, as well as in an area of brain parenchyma where white matter lesions (leukoaraiosis) can be found, in patients with clinically unmanifested cerebrovascular atherosclerosis. Methods and results( Arterial specimens from the basilar artery and middle cerebral artery, and brain samples from the basal ganglia and periventricular white matter were obtained. Neuropathological changes were assessed in Haematoxylin-Eosin stained sections. Polymerase chain reaction (PCR) was performed on paraffin embedded sections. Subsequently, we performed immunohistochemical staining on samples, which were found positive in PCR. We failed to detect C. pneumoniae, CMV, or HSV-1, in any of the cerebral large vessels. In the brain tissue, we found only one case positive for CMV, and one for C. pneumoniae. Conclusions (our findings suggest a limited role for C. pneumoniae, CMV and HSV-1 in cerebral large and small vessel atherosclerosis. |
| Databáze: | OpenAIRE |
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