Pharmacological fMRI: Effects of subanesthetic ketamine on resting-state functional connectivity in the default mode network, salience network, dorsal attention network and executive control network
| Autor: | Georg Winterer, Francesco Musso, Felix Mueller, Peter de Boer, Norman Zacharias, Markus London |
|---|---|
| Přispěvatelé: | Radiotherapy, Graduate School |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cognitive Neuroscience Intraparietal sulcus lcsh:Computer applications to medicine. Medical informatics lcsh:RC346-429 03 medical and health sciences Executive Function Young Adult 0302 clinical medicine Double-Blind Method Task-positive network medicine Humans Radiology Nuclear Medicine and imaging Attention Resting-state fMRI Default mode network lcsh:Neurology. Diseases of the nervous system Cross-over fMRI study Cross-Over Studies medicine.diagnostic_test Resting state fMRI business.industry Brain Regular Article Subanesthetic ketamine effects Correlation testing Magnetic Resonance Imaging 030227 psychiatry Dorsolateral prefrontal cortex medicine.anatomical_structure Neurology Superior frontal gyrus Posterior cingulate lcsh:R858-859.7 Ketamine Neurology (clinical) Nerve Net Function and Dysfunction of the Nervous System Functional magnetic resonance imaging business Neuroscience Excitatory Amino Acid Antagonists 030217 neurology & neurosurgery Seed-to-voxel fMRI analysis |
| Zdroj: | NeuroImage: Clinical, Vol 19, Iss, Pp 745-757 (2018) NeuroImage : Clinical NeuroImage. Clinical, 19, 745-757. Elsevier BV |
| ISSN: | 2213-1582 |
| Popis: | Background Subanesthetic dosages of the NMDAR antagonist, S-Ketamine, can cause changes in behavior in healthy subjects, which are similar to the state acute psychosis and are relevant in translational schizophrenia research. Functional magnetic resonance imaging (fMRI) can be used for non-hypothesis-driven analysis of brain connectivity. The correlation between clinical behavioral scores and neuroimaging can help to characterize ketamine effects on healthy brains in resting state. Method seventeen healthy, male subjects (mean: 27.42 years, SD: 4.42) were administered an infusion with S-Ketamine (initial bolus 1 mg/kg and continuous infusion of 0.015625 mg/kg/min with dosage reduction −10%/10 min) or saline in a randomized, double-blind, cross-over study. During infusion, resting state connectivity was measured and analyzed with a seed-to-voxel fMRI analysis approach. The seed regions were located in the posterior cingulate cortex, intraparietal sulcus, dorsolateral prefrontal cortex and fronto-insular cortex. Receiver operating characteristics (ROC) were calculated to assess the accuracy of the ketamine-induced functional connectivity changes. Bivariate Pearson correlation was used for correlation testing of functional connectivity changes with changes of clinical scores (PANSS, 5D-ASC). Results In the executive network (ECN), ketamine significantly increases the functional connectivity with parts of the anterior cingulum and superior frontal gyrus, but no significant correlations with clinical symptoms were found. Decreased connectivity between the salience network (SN) and the calcarine fissure was found, which is significantly correlated with negative symptoms (PANSS) (R2 > 0.4). Conclusion Decreased ketamine-induced functional connectivity in the salience network may qualify as accurate and highly predictive biomarkers for ketamine induced negative symptoms. Highlights • All seed regions showed ketamine induced changes of functional connectivity • Signficant changes of functional connectivity were found in the salience and executive control network • PANSS and 5D-ASC scores are highly sensitive and specific to differentiate between placebo and ketamine condition • A significant correlation between salience network- visual cortex connectivity and negative symptom scores was found |
| Databáze: | OpenAIRE |
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