New Fissure-Attached Nodules in Lung Cancer Screening: A Brief Report From The NELSON Study
| Autor: | Lisa H. van Smoorenburg, Harry J. de Koning, Carlijn M. van der Aalst, Kristiaan Nackaerts, Matthijs Oudkerk, Marjolein A Heuvelmans, Daiwei Han, Rozemarijn Vliegenthart, Joan Walter, Monique D. Dorrius, Harry J.M. Groen, Mieneke Rook |
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| Přispěvatelé: | Public Health, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Cardiovascular Centre (CVC) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Male medicine.medical_specialty Lung Neoplasms Intrapulmonary lymph nodes INTRAPULMONARY LYMPH-NODES Pulmonary nodule 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Interquartile range Medicine Humans Mass Screening Lung cancer Early Detection of Cancer Lung business.industry Incidence (epidemiology) Solitary Pulmonary Nodule Nodule (medicine) Middle Aged medicine.disease PROBABILITY Editorial Commentary 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Screening Multiple Pulmonary Nodules PERIFISSURAL NODULES TRIAL Female Radiology medicine.symptom business Tomography X-Ray Computed Lung cancer screening |
| Zdroj: | Journal of Thoracic Oncology, 15(1), 125-129. International Association for the Study of Lung Cancer Ann Transl Med Journal of Thoracic Oncology, 15(1), 125-129. ELSEVIER SCIENCE INC |
| ISSN: | 1556-0864 |
| Popis: | INTRODUCTION: In incidence lung cancer screening rounds, new pulmonary nodules are regular findings. They have a higher lung cancer probability than baseline nodules. Previous studies have shown that baseline perifissural nodules (PFNs) represent benign lesions. Whether this is also the case for incident PFNs is unknown. This study evaluated newly detected nodules in the Dutch-Belgian randomized-controlled NELSON study with respect to incidence of fissure-attached nodules, their classification, and lung cancer probability. METHODS: Within the NELSON trial, 7557 participants underwent baseline screening between April 2004 and December 2006. Participants with new nodules detected after baseline were included. Nodules were classified based on location and attachment. Fissure-attached nodules were re-evaluated to be classified as typical, atypical, or non-PFN by two radiologists without knowledge of participant lung cancer status. RESULTS: One thousand four hundred eighty-four new nodules were detected in 949 participants (77.4% male, median age 59 years [interquartile range: 55-63 years]) in the second, third, and final NELSON screening round. Based on 2-year follow-up or pathology, 1393 nodules (93.8%) were benign. In total, 97 (6.5%) were fissure-attached, including 10 malignant nodules. None of the new fissure-attached malignant nodules was classified as typical or atypical PFN. CONCLUSIONS: In the NELSON study, 6.5% of incident lung nodules were fissure-attached. None of the lung cancers that originated from a new fissure-attached nodule in the incidence lung cancer screening rounds was classified as a typical or atypical PFN. Our results suggest that also in the case of a new PFN, it is highly unlikely that these PFNs will be diagnosed as lung cancer. ispartof: JOURNAL OF THORACIC ONCOLOGY vol:15 issue:1 pages:125-129 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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