Topical Delivery of Senicapoc Nanoliposomal Formulation for Ocular Surface Treatments
| Autor: | Tanima Bose, Subbu S. Venkatraman, Aihua Hou, Louis Tong, Yuan Siang Lui, George K. Chandy, Yingying Huang, Jie Liang Phua |
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| Přispěvatelé: | School of Electrical and Electronic Engineering, Lee Kong Chian School of Medicine (LKCMedicine) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Drug
liposomes Male media_common.quotation_subject Senicapoc Administration Topical 02 engineering and technology Poloxamer 010402 general chemistry Eye 01 natural sciences Catalysis Article ocular Inorganic Chemistry lcsh:Chemistry Rats Sprague-Dawley Drug Delivery Systems Pharmacokinetics senicapoc Acetamides Animals Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy media_common Liposome Drug Carriers Chemistry Organic Chemistry Hydrogels Trityl Compounds General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Computer Science Applications Bioavailability Rats Engineering::Materials [DRNTU] lcsh:Biology (General) lcsh:QD1-999 Self-healing hydrogels Liposomes hydrogel 0210 nano-technology Ocular surface Biomedical engineering |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 19, Iss 10, p 2977 (2018) Volume 19 Issue 10 |
| ISSN: | 1422-0067 |
| Popis: | Topical ophthalmologic treatments have been facing great challenges with main limitations of low drug bioavailability, due to highly integrative defense mechanisms of the eye. This study rationally devised strategies to increase drug bioavailability by increasing ocular surface residence time of drug-loaded nanoliposomes dispersed within thermo-sensitive hydrogels (Pluronic F-127). Alternatively, we utilized sub-conjunctival injections as a depot technique to localize nanoliposomes. Senicapoc was encapsulated and sustainably released from free nanoliposomes and hydrogels formulations in vitro. Residence time increased up to 12-fold (60 min) with 24% hydrogel formulations, as compared to 5 min for free liposomes, which was observed in the eyes of Sprague-Dawley rats using fluorescence measurements. Pharmacokinetic results obtained from flushed tears, also showed that the hydrogels had greater drug retention capabilities to that of topical viscous solutions for up to 60 min. Senicapoc also remained quantifiable within sub-conjunctival tissues for up to 24 h post-injection. NMRC (Natl Medical Research Council, S’pore) Published version |
| Databáze: | OpenAIRE |
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